{"product_id":"metabo-assist-120-ct","title":"Metabo-Assist 120 ct","description":"\u003cp\u003eMetabo-Assist is a high-concentration, highly purified\u003cbr\u003epolyphenolic blend that has been scientifically demonstrated\u003cbr\u003eto make positive shifts in functional metabolic targets.\u003cbr\u003eIt provides multidimensional support to maintain blood\u003cbr\u003epressure levels already within the normal range, manage\u003cbr\u003eweight, and increase satiety and appetite control. Metabo-Assist\u003cbr\u003eprovides a potent formula for those seeking to optimize their\u003cbr\u003emetabolism and cardiovascular health.\u003cbr\u003eOverview\u003cbr\u003eMaintaining healthy blood pressure levels has become a primary\u003cbr\u003econcern for many in the United States and across the globe.\u003cbr\u003eBlood pressure fluctuations cause a variety of cardiovascular\u003cbr\u003echallenges, and this is one of the most common cardiometabolic\u003cbr\u003echallenges experienced. In the Framingham study, the risk of\u003cbr\u003ehaving blood pressure challenges over a lifetime was 90%,\u003cbr\u003ewhile it is estimated that the global burden will increase to\u003cbr\u003e1.56 billion by 2025.1\u003cbr\u003e While traditional therapies are available,\u003cbr\u003emost are not well-tolerated, making diet and lifestyle changes,\u003cbr\u003esuch as whole food-based diets, increasing physical activity and\u003cbr\u003etargeted nutrient support, the optimal way to maintain blood\u003cbr\u003epressure levels already within the normal range.2\u003cbr\u003eThere is abundant evidence that dietary factors play a central\u003cbr\u003erole in determining cardiovascular risk driven by several\u003cbr\u003epotential mechanisms.3\u003cbr\u003e Among various factors determining\u003cbr\u003ehuman health, dietary patterns such as the Mediterranean\u003cbr\u003ediet or the DASH diet model have been demonstrated to play\u003cbr\u003ea role in helping maintain vascular health and preserving\u003cbr\u003eoptimal blood pressure levels.4\u003cbr\u003e A common feature of such\u003cbr\u003edietary patterns is the richness in plant-derived foods, which\u003cbr\u003eare high in fiber and phytochemicals proven to be antioxidant\u003cbr\u003epowerhouses. Polyphenols are a large group of plant\u003cbr\u003emetabolites that exert a variety of key biological activities\u003cbr\u003eincluding increasing satiety hormones (like GLP-1 [glucagonlike peptide-1]) and decreasing hunger hormones (like\u003cbr\u003eghrelin). In addition, targeted plant bioactives have also been\u003cbr\u003eshown to stimulate 5’adenosine monophosphate-activated\u003cbr\u003eprotein kinase (AMPK), which has been shown to be a primary\u003cbr\u003eactivating mechanism for human metabolism. AMPK may\u003cbr\u003ecreate such positive effects through its capability to modulate\u003cbr\u003eenergy homeostasis, total daily energy expenditure, lipid\u003cbr\u003eoxidation and metabolism.5\u003cbr\u003eHiPhenolic provides a targeted blend of key polyphenols that\u003cbr\u003emaintain energy and metabolic efficiency, maintain normal\u003cbr\u003eblood pressure levels, and support overall cardiometabolic\u003cbr\u003efunction.\u003cbr\u003eMetabolaid®\u003cbr\u003e(Hibiscus and Lemon Verbena Extract)\u003cbr\u003eLemon verbena (Lippia citriodora) has been used as a food\u003cbr\u003espice, cosmetic, and in traditional formulations in South\u003cbr\u003eAmerica and Southern Europe. Hibiscus flower (Hibiscus\u003cbr\u003esabdariffa L.) is used in traditional Chinese formulations in\u003cbr\u003ethe manner of a tea to help maintain normal blood pressure\u003cbr\u003elevels and normal inflammatory balance. Metabolaid® is a\u003cbr\u003ecombination of the plant polyphenols in lemon verbena and\u003cbr\u003ehibiscus flower extracts. These extracts have been shown to\u003cbr\u003ework synergistically on the activation of the energy sensor\u003cbr\u003eAMPK and promote optimal metabolic efficiency through the\u003cbr\u003emodulation of fat metabolism.\u003cbr\u003e• Multidimensional Support for Optimal Blood Pressure Levels\u003cbr\u003e• Helps Enhance Metabolic Activity and Efficiency\u003cbr\u003e• Aids in Supporting Optimal Weight and Reducing Cravings\u003cbr\u003e• Supports Healthy Cardiometabolic Function\u003cbr\u003e CLINICAL APPLICATIONS\u003cbr\u003eCARDIOVASCULAR HEALTH\u003cbr\u003e\u003cbr\u003e† These statements have not been evaluated by the Food and Drug Administration.\u003cbr\u003eThis product is not intended to diagnose, treat, cure, or prevent any disease.\u003cbr\u003eIn a 2018 double-blind, placebo-controlled and randomized\u003cbr\u003etrial in 56 subjects with weight management challenges,\u003cbr\u003eparticipants were given 500 mg of a combination of\u003cbr\u003epolyphenolic extracts from Lippia citriodora and Hibiscus\u003cbr\u003esabdarifa L. for two months and showed significant\u003cbr\u003eimprovement in body weight, abdominal circumference, and\u003cbr\u003ebody fat percentage. Heart rate and systolic blood pressure\u003cbr\u003ealso were maintained within the normal range.6\u003cbr\u003e In another\u003cbr\u003eeight-week, randomized, double-blind, placebo-controlled\u003cbr\u003etrial, 54 participants given the same extract showed an\u003cbr\u003eimprovement of anthropometric measurements, maintenance\u003cbr\u003eof blood pressure within the normal range, and improved\u003cbr\u003eheart rate. In addition, they experienced positive perception\u003cbr\u003eof overall health status. This polyphenolic combination has\u003cbr\u003ebeen shown to significantly increase metabolic function and\u003cbr\u003esupport healthy weight by decreasing appetite biomarkers.\u003cbr\u003eThis may help to avoid the undesired weight rebound typical\u003cbr\u003eof calorie restriction diets.5\u003cbr\u003eGreen Coffee Bean Extract\u003cbr\u003eCoffee is one of the most consumed drinks in the world. Green\u003cbr\u003ecoffee beans are the beans from the Coffea fruit that have not\u003cbr\u003eyet been roasted. Coffee beans are naturally high in chlorogenic\u003cbr\u003eacid, and roasting them reduces the chlorogenic acid content.\u003cbr\u003eChlorogenic acid, a polyphenol, is what holds the antioxidant\u003cbr\u003eproperties and increases the overall health benefits of coffee;7\u003cbr\u003etherefore, the effects and benefits of coffee are maximized in\u003cbr\u003eits natural and unroasted state. In addition, the green coffee\u003cbr\u003ebean extract in Metabo-Assist has had the caffeine removed, so\u003cbr\u003ethe benefits of the polyphenols can be maximized.\u003cbr\u003eA meta-analysis of nine randomized, controlled trials with\u003cbr\u003egreen coffee bean extract (GCBE) administered for four\u003cbr\u003eweeks showed a benefit in maintaining blood pressure levels\u003cbr\u003ealready in the normal range—both systolic and diastolic.8\u003cbr\u003e In\u003cbr\u003eanother systemic review and meta-analysis study consisting\u003cbr\u003eof 637 participants, it was shown that green coffee bean\u003cbr\u003eextract consumption can help maintain optimal lipid markers,\u003cbr\u003edecrease body weight, and improve metabolism and glucose\u003cbr\u003edisposal.9\u003cbr\u003e Finally, in a randomized clinical trial, 43 subjects\u003cbr\u003econsumed GCBE for eight weeks. After supplementation, all\u003cbr\u003eindices of cardiovascular health showed benefits. Additionally,\u003cbr\u003ewaist circumference and appetite score of the individuals\u003cbr\u003esupplemented with GCBE indicated a significant decline.10\u003cbr\u003eMagnesium Citrate\u003cbr\u003eMagnesium is a cofactor in more than 300 enzyme systems\u003cbr\u003ethat regulate diverse biochemical reactions in the body,\u003cbr\u003eincluding protein synthesis, muscle and nerve function,\u003cbr\u003eblood glucose control, and blood pressure regulation.11-13\u003cbr\u003eMagnesium is required for energy creation, which involves\u003cbr\u003eoxidative phosphorylation and glycolysis. It contributes to the\u003cbr\u003edevelopment of bone and is required for the synthesis of DNA,\u003cbr\u003eRNA, and the antioxidant glutathione. Magnesium also plays\u003cbr\u003ea role in the active transport of calcium and potassium ions\u003cbr\u003eacross cell membranes, a process that is important to nerve\u003cbr\u003eimpulse conduction, muscle contraction, and normal heart\u003cbr\u003erhythm.13 The role of magnesium as an enzyme cofactor for\u003cbr\u003eactivities that generate adenosine triphosphate (ATP) highlight\u003cbr\u003eits significance for maintaining energy levels and metabolic\u003cbr\u003eefficiency.\u003cbr\u003eA meta-analysis of randomized, double-blind, placebo controlled studies on the effects of magnesium\u003cbr\u003esupplementation on blood pressure showcased 34 trials\u003cbr\u003einvolving 2,028 participants who, while using magnesium\u003cbr\u003esupplementation with a median duration of three months,\u003cbr\u003eshowed benefits in maintaining systolic and diastolic blood\u003cbr\u003epressure within the normal range for adults.14,15 Overall, oral\u003cbr\u003emagnesium citrate supplementation has been shown to\u003cbr\u003emaintain healthy blood pressure and blood sugar markers.15\u003cbr\u003eDirections\u003cbr\u003e2 capsules per day or as recommended by your health care\u003cbr\u003eprofessional.\u003cbr\u003eDoes Not Contain\u003cbr\u003eGluten, corn, yeast, artificial colors or flavors.\u003cbr\u003eCautions\u003cbr\u003eDo not consume this product if you are pregnant or nursing.\u003cbr\u003eConsult your physician for further information.\u003c\/p\u003e","brand":"Preckshot Pharmacy","offers":[{"title":"Default Title","offer_id":49014552690942,"sku":"pqh1789987039455","price":48.74,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0743\/8781\/6702\/files\/metabo-assist-120-ct_1.jpg?v=1789987069","url":"https:\/\/www.wisehaul.shop\/products\/metabo-assist-120-ct","provider":"Celunique","version":"1.0","type":"link"}